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Common negative reports include increased injection site discomfort, slightly more GI upset (particularly during the first few weeks), and disappointment when the dramatic results promised by marketing materials do not materialize

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Knowing which foods to avoid while on tirzepatide helps manage GI side effects, but autoimmune patients should ensure that any dietary restrictions do not compromise their already-elevated nutritional needs

doi:10.1001/jama.2023.12055

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If prescribed, metoclopramide should be used with caution and for short durations due to the risk of tardive dyskinesia and other neurological side effects