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10.1038/nature11087 Nature 10 Bernardo-CastroS.SousaJ

Patients with severe gastrointestinal disease, particularly gastroparesis, may experience worsening symptoms due to semaglutide's effects on gastric emptying and may not be suitable candidates

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SURMOUNT-1, NEJM 2022 57% Lost 20% Body Weight Furthermore, more than half of patients achieved weight loss previously seen only with bariatric surgery

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To help provide insights into the potential role of oral semaglutide in current T2D management, this article aims to discuss the pharmacology of oral semaglutide, review the current clinical evidence on the efficacy and safety of this agent from the extensive phase III PIONEER clinical trial program in patients with T2D, and describe findings from initial cost-effectiveness studies