dpp 4 inhibitor glp 1 agonist Role of Dipeptidyl Peptidase Inhibitors in Antidiabetic Treatment GLP-1 Receptor Agonists Have better

Li Y, Glotfelty EJ, Namdar I, Tweedie D, Olson L, Hoffer BJ, et al

Acute Pancreatitis: Based on spontaneous postmarketing reports, acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with liraglutide

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Dulaglutide is approved for T2DM management (Sanford, 2014), offering glycemic control and weight loss benefits comparable to liraglutide but with the added convenience of a weekly dosing regimen (Chang et al., 2020)

Future generations of incretin agonists may be able to maintain the reduction in blood glucose and body weight while minimizing these off-target effects

The second mechanism is characterized by the modulation of intracellular calcium, which seems to function as a trigger for rapid insulin exocytosis and complements the amplification phenomena [8]