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Contact your healthcare provider if you experience: Severe or persistent cramps that do not respond to self-care measures or significantly impact your quality of life and daily activities Frequent cramping occurring multiple times daily or nightly, disrupting sleep and functioning Associated symptoms including muscle weakness, numbness, tingling, or changes in sensation, which may suggest neurological involvement Swelling, redness, or warmth in the affected leg, which could indicate deep vein thrombosis or other vascular complications Severe gastrointestinal symptoms with signs of dehydration such as decreased urination, dizziness, confusion, or rapid heartbeat Cramps that began after starting semaglutide and persist despite adequate hydration and nutritional measures Seek immediate medical attention (call 911) if you develop: Chest pain, shortness of breath, or severe abdominal pain Signs of severe dehydration including inability to keep down fluids, minimal urine output, or altered mental status Symptoms suggesting acute kidney injury, such as significantly decreased urination, swelling, or confusion Your healthcare provider can perform a comprehensive evaluation including physical examination, review of your medication regimen, and laboratory testing to assess electrolyte levels, kidney function, and other relevant parameters

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Key Takeaways Retatrutide (LY3437943) is an investigational weight loss medication developed by Eli Lilly Triple-agonist mechanism: First drug to activate GLP-1, GIP, and glucagon receptors simultaneously Phase 2 results: Up to 24.2% weight loss at 48 weeks (approximately 58 lbs for a 240-lb person) Not FDA-approved: Currently in Phase 3 clinical trials, expected approval in 20272028 How it differs: Outperforms semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound) in weight loss trials Access now: Clinical trials (free), compounding pharmacies, or research peptide vendors What Is Retatrutide