glp-1 and surgery risk Are medications helping—or complicating—surgical recovery? A new PRS Journal article explores their perioperative safety in nonbariatric patients undergoing panniculectomy, including postoperative complications GLP-1–related adverse effects The Safety of GLP1 Receptor

28,29 While not associated with clinical benefit in HFrEF, recently, these drugs have been studied in patients with HFpEF demonstrating improvements in clinical outcomes such as health-related quality of life (STEP-HFpEF) as well as reductions in cardiovascular death and HF events (SUMMIT)

These data provide a potential mechanism by which central GLP-1 receptor stimulation modulates parasympathetic outflow to the heart and increases heart rate

For many patients, GLP-1s and multi-agonists like Lillys GLP-1/GIP Tirzepatide are godsends

ATP channel, increasing K ATP channel sensitivity to ATP and leading to K ATP channel closure, cell membrane depolarization and VDC channel opening, followed by Ca 2+ influx through VDC channels into cells to promote the exocytosis of insulin granules and the acute secretion of insulin and into circulation (Mller et al., 2019) (Figure 2)

Many women never receive this warning

Figure 3 ), enhancing bone mass and strength in preclinical models of T2DM (120), and is thought to play an important role in enhancing cognition ( (121)