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10 Although obesity is a well-recognized risk factor for the development of left atrial myopathy and AF, 11 it is noteworthy that the prevalence of AF was comparable (and not higher) in the setting of obesity-related HFpEF vs the broader HFpEF patient populations

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TRZ alters leptin sensitivity by upregulating adiponectin and enhancing the leptin-adiponectin axis, improving hippocampal function

The drug tirzepatide (Mounjaro and Zepbound) is a dual GLP-1 and GIP receptor agonist, making its mechanism distinct from semaglutide (Ozempic and Wegovy) and other competitors, which are strictly GLP-1 agonists

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