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It will be difficult to engineer balanced agonism into a single small-molecule because the sequence hybridisation of the dual and triple peptide agonists has no obvious chemical analogue

Global assessment of the evidence The Modified Bradford Hill Criteria was used to assess the potential relationships among various available evidence [33,34,35]

The two major incretins, glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP), are secreted from the intestinal enteroendocrine cells in response to nutrient intake

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The change in MBV can be considered substantial, given that even small increases in tissue MBV markedly improve oxygen supply when tissue total blood flow is limited, such as in the presence of coronary atherosclerosis