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controls at 1 year, but there was no significant difference in insulin dose between the semaglutide and control groups
Patients tolerating a once-weekly GLP-1 receptor agonist at the maximal therapeutic dose should start the alternative once-weekly agent 1 week after the last dose of the current treatment

For example, why do people with diabetes lose less weight than obese, non-diabetics (first Figure from this post expanded to show the difference for the various drugs)

After 4 months, men on liraglutide had a +46% increase in total testosterone, along with significant increases in LH and FSH (indicating improved endogenous gonadotropin output)mdpi.com