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Biologic GLP-1 receptor agonists are produced using recombinant technology

In rodents, GLP-1 has been shown to increase the biosynthesis of glucose transporter 2 (GLUT-2) and glucokinase [29]

A Swedish national study has shown that girls in the obese cohort have a 43% higher risk of anxiety and depression compared to girls in the general population (adjusted HR: 1.43, 95% CI: 1.311.57

Eleven large CVOTs have investigated the impact of GLP-1RAs on major adverse cardiovascular events (MACE) defined as a composite of CV death, nonfatal MI, and nonfatal stroke or on maximum walking distance in peripheral artery disease (57, 58)

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