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PNPLA3 has hydrolase activity on triglycerides, and the I148M genetic variant is associated with a functional loss of this activity, which promotes the accumulation of triglycerides in hepatocytes and favors the development of hepatic steatosis 62
If that is still too expensive, metformin at $4-10 per month provides modest but real benefits, and phentermine at $15-30 per month offers the cheapest significant appetite suppression available
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One primary mechanism is slowing the emptying of the stomach, resulting in a sense of fullness over a longer period of time
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