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DPP-4 inhibitors, such as sitagliptin, alogliptin, linagliptin and saxagliptin, were synthesized to prolong the half-life of GLP-1 (102)

These divergent findings likely reflect heterogeneity in study design, mechanisms of action of the drugs evaluated, duration of follow-up, and the degree of metabolic phenotyping across populations

8:19-28 [PMC free article: PMC8109335] [PubMed: 16407685] 88

however, this program was discontinued in April 2025 following a potential drug-induced liver injury signal and earlier tolerability concerns, leaving orforglipron as the leading oral small-molecule GLP-1RA in late-stage development