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In head-to-head comparisons, tirzepatide has consistently shown greater average weight loss than semaglutide
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Pratap-Singh, A., Guo, Y., Baldelli, A., & Singh, A

Have complex medical histories

Long-Term Safety Considerations As a relatively new class of medications, the long-term safety profile of GLP-1 agonists is still under evaluation

Nevertheless, GLP-1 presented a rather ephemeral circulatory half-life, lasting a mere 12 min, due to the rapid enzymatic degradation by dipeptidyl peptidase IV (DPP-4), which markedly limits its biological efficacy [35]
