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While patients with minimal alcohol use (up to 20/30 g/d in women/men) were enrolled in the ESSENCE trial, those with higher alcohol consumption [ie, in the MetALD (metabolic dysfunction and alcohol-associated liver disease) range] were excluded

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Physiology of peripheral and central GLP-1 signaling GLP-1 is a 30-amino acid peptide synthetized by enteroendocrine L cells of the small and large intestine, and also in the brain primarily by neurons of the nucleus tractus solitarius (NTS) within the caudal brainstem as a product of tissue-specific posttranslational cleavage of a larger precursor molecule preproglucagon (PPG)