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However, recent work suggests that there is sufficient expression of GLP-1r on -cells for direct regulation as well

Obesity leads to a constant state of low-grade inflammation, which not only makes arthritis pain and swelling worse but also raises your risk for diabetes, heart attacks, and even early death

Nat Rev Urol 12:263270 Upala S, Jaruvongvanich V, Sanguankeo A (2016) Risk of nephrolithiasis, hyperoxaluria, and calcium oxalate supersaturation increased after Roux-en-Y gastric bypass surgery: a systematic review and meta-analysis

Weaning off a drug can differ from person to person

The main reason is that GLP-1 is a peptide

And for others, it can help them taper off a GLP-1 while reducing their risk of rebound weight gain especially if they pair it with other lifestyle changes like regular physical activity and a nutritious diet