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What studies show: In a 56-week clinical trial of adults with obesity or overweight, people taking liraglutide lost an average of about 18.5 pounds vs

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Higher weight-loss doses of semaglutide and tirzepatide both report more diarrhea, especially early and after dose increases

This faster regain could be because people using drugs dont need to consciously practise changing their diet to lose weight, so when they stop taking the medication, they might not have developed the practical strategies that could help them keep it off, said senior author and Oxford associate professor Dimitrios Koutoukidis in an official statement

On the other hand, more recent work suggests that GIP analogs lower body weight via GIPR agonism 150,151