biomarkers for glp-1 agonists The dual GCGR/GLP‐1R agonist survodutide: and pharmacological profiling clinical candidate selection - Thomas - 2024 - Diabetes, Obesity and Metabolism GLP-1 Agonists Guide: Biomarkers, Genetics

Glucagon-Like Peptide 1 Receptor Agonists and the Eye AT A GLANCE Glucagon-like peptide 1 receptor agonists (GLP-1RA) are FDA-approved for treating type 2 diabetes and are commonly used in weight loss regimens

Ethics declarations Conflicts of Interest Financial interests: ZM has stock in Novo Nordisk Pharmaceuticals and served as a consultant for Neptune Medical

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SGLT2 inhibitors remove glucose through urine, which increases calorie loss and can mimic a state of fasting

Abbreviations: VTA: ventral tegmental area, NAc: nucleus accumbens, NTS: nucleus tractus solitarius, LH: lateral hypothalamus, DMHipp: dorsomedial hippocampus, LDTg: laterodorsal tegmental nucleus, LS: lateral septum, CeA: central amygdala, PVN: paraventricular nucleus, DA: dopamine, : decreased, : increased, MAO-A: monoamine oxidase A, COMT: catechol-O-methyltransferase, D1-MSN: D1-type medium spiny neuron, OX1R: orexin-1 receptor, HPA: hypothalamicpituitaryadrenal axis

The 3 rd investigator (LW) was consulted to resolve disagreements