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An effect was observed at T0 before the glucose challenge but already after 30 min (60 min after dosing) there was no significant effect on the blood glucose for peptide 1 in agreement with previous IPGTT study

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Mechanism of Action Dual Neurotransmitter Reuptake Inhibition Duloxetine increases serotonin and norepinephrine levels in the brain

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Phase 2: creatine introduction (weeks 5-6) Once GI side effects are manageable (not necessarily gone, just manageable), introduce creatine at 3 grams daily