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GLP-1 RAs may significantly increase the risk of neovascular age-related macular degeneration in older adults with diabetes.

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Mean diabetes duration was 2.5 years

Compared with diabetic patients who did not use GLP-1 RAs having an incidence of 12.85 per 1000 person-years, the adjusted hazard ratio (HR) of DR was 0.42 [95% confidence interval (CI), 0.290.61]