is zepbound semaglutide or tirzepatide GLP-1 receptor agonists, including (Wegovy/Ozempic) and (Mounjaro/Zepbound), are being recognized for benefits beyond blood sugar control and weight management. New real-world evidence suggests they may also play a role in Zepbound (tirzepatide) superior to Wegovy

Which naturally raises the question for biopharma investors and developers alike what therapeutic area could repeat this success

Efficacy and safety of tirzepatide, GLP-1 receptor agonists, and other weight loss drugs in overweight and obesity: a network metaanalysis

Tejero Garca, S

At the same time, there is growing recognition that GLP-1 therapy reduces hepatic steatosis, triglycerides, and systemic inflammation

The science: Muscle tissue is metabolically activeit generates heat even at rest Studies show that without adequate protein intake and resistance training, up to 25% of weight lost can be lean muscle mass Muscle has a higher metabolic rate than fat tissue (~13 kcal/kg/day for muscle vs ~4.5 kcal/kg/day for fat) Why you feel cold: Less muscle = less heat production

"In studies, most nausea, vomiting and diarrhea events occurred while the dose of Mounjaro was being increased