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Their benefits go beyond glycemic control, suggesting potential as a key treatment for cardiovascular diseases
Design In the obesity trial, 338 participants (mean age 48 years, 48% women, mean BMI 37.3 kg/m 2 ) were randomised (2:1:1:1:1:2:2) to retatrutide 1 mg, 4 mg (titration), 4 mg (no titration), 8 mg (slow titration), 8 mg (fast titration), 12 mg or placebo over 48 weeks [45]
J&Js key growth drivers include its oncology portfolio (e.g., Darzalex for multiple myeloma, with USD 12B+ projected 2025 sales) and immunology blockbusters like Stelara (ustekinumab), which generated USD 11B in 2023 and faces biosimilar competition post-patent expiry
Additionally, it significantly reduced the activation of CASP3, a crucial component of apoptotic pathways
Injectable Pen Segment is Expected to Drive the GLP-1 Drug Biosimilar Market The market share of the Injectable Pen segment was the largest in 2025
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