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however, only the main chain Arg can be produced by the gene recombination technology 34 -GLP-1 9-37 The method also needs to utilize chemical means and His-Aib reaction to generate the semaglutide main chain Aib 8 ,Arg 34 -GLP-1 7-37 (ii) a Then at Lys 26 The side chain amino is connected with a long-acting modification group