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There are currently no robust studies showing that smaller doses deliver the same cardiovascular or metabolic advantages, or even that they work consistently at all

Companies discontinued agents like Lixisenatide and Albiglutide, while the approval of combination therapies like Liraglutide/insulin-degludec highlights the role of GLP-1 receptor agonists in diabetes and obesity management (23)(25)

Persistence and Adjacent Indications Persistence or the length of time patients stayed on GLP-1s also varied by patients overall disease burden, weight loss and HbA1c measures at initiation

Some people simply eat less overall, which may result in lower intake of essential nutrients

How much longer

Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC