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Real-world evidence from observational studies consistently shows that GLP-1 RA use is associated with reduced risk of hepatic decompensation even in patients with established cirrhosis, supporting cautious use in this population

Dose adjustments should be considered if free testosterone levels or symptoms change materially with weight loss

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Maintenance dosing means using only as much medicine as you need to hold results stable, not to shed any additional weight

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However, GIP appears to synergise the central satiety effect and weight loss linked with GLP-1
