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In Phase 2 and early Phase 3 trials, the most common side effects were gastrointestinal, including nausea, diarrhea, vomiting, and constipation, which were generally mild-to-moderate and dose-dependent

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this does not constitute a confirmed contraindication under current UK or EU guidance

also declares personal honoraria/lecture fees from AstraZeneca, Boehringer Ingelheim, Medscape, Napp, Menarini, Novo Nordisk and Rhythm

All research protocols were reviewed and approved by the Amgen Institutional Animal Care and Use Committee (Thousand Oaks, CA), Toronto Centre for Phenogenomics at Mount Sinai Hospital (Toronto, Canada) and Danish Animal Experimentation Council (Hrsholm, Denmark)