dulaglutide vs tirzepatide for Cardiovascular Outcomes (SURPASS-CVOT) | NEJM Management of type 2 diabetes

Schauer PR et al

While some physicians prescribe combination therapy, semaglutide's superior efficacy and side effect profile make dual therapy rarely necessary

Distribution and pharmacy markups add another 20-30% to the final patient cost

Differences From Injectable Semaglutide Semaglutide nasal spray differs from the injectable form in absorption rate, administration, and potential tolerability: Absorption: Intranasal delivery offers quicker onset due to rapid mucosal uptake, with studies highlighting faster plasma appearance versus subcutaneous injection (Novo Nordisk, 2023 Phase 1 results)

At Sunset Primary Care, we charge $225/month for our Semaglutide weight loss plan

Mod Pathol (2015) 28(3):391402