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16 On the other hand, the investigational use of GIPR agonists (GIPRAs) has not yielded similar advantages, partly because of a lack of understanding of GIP dose-response actions

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The development of multiagonists, including GLP-1glucagon and GIPGLP-1glucagon receptor agonists, especially with the potential for glucagon receptor activation, marks a significant advancement in the field

Additionally, patients taking oral semaglutide also showed improvements in multiple cardiovascular metabolic risk factors

Lillys approval for Mounjaro in Obesity will result in a duopoly in the space, with clinical stage biopharma (mentioned below) likely 2 years from having a drug on the market