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Continued treatment sustains results, with weight regain occurring gradually if semaglutide is discontinued without lifestyle maintenance

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In recent decades, the global population has witnessed a significant increase in the prevalence of overweight and obese individuals (Wong et al., 2022)

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GLP-1 receptors, which are expressed in the central nervous system (CNS) in addition to peripheral tissues, are limited to neurons in the caudal nucleus of the solitary tract (NTS) and the ventrolateral medulla in the brainstem and hypothalamus (1517)
