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Doctors and researchers are already jokingly referring to retatrutide as the "King Kong" for weight loss because early results in clinical trials suggest it rivals bariatric surgery, and it seems to protect more lean muscle mass

As studies continue, researchers say the medications are increasingly being examined not only as metabolic treatments, but also as drugs that may influence brain function, behavior and emotional regulation

Despite this, GLP-1 can impact glucose homeostasis via a gutbrain neuronal axis, independent of changes in insulin secretion

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Muscle loss requires individual protein and training targets, assessed against actual lean mass rather than a generic guideline