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Most research comes from animal studies, not people

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Reduction of Homeostatic Model AssessmentInsulin Resistance (HOMA-IR) score promoted by double treatment with GLP-1RAs and metformin has been significant, unlike reduction of HOMA-IR score promoted by metformin treatment only

That year two different groups published papers indicating that secretin could lower blood glucose

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Most GLP-1R agonists have gastrointestinal side effects, including nausea, vomiting, diarrhea and constipation, which may be more pronounced in elderly patients with AD and affect treatment compliance