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Remember that upper arm injections often require assistance from another person

PERK, PKR-like ER kinase

GLP-1 activates the GLP-1R to stimulate adenylate cyclase (AC), increasing intracellular levels of cyclic AMP (cAMP) (Sandoval and DAlessio, 2015)

The GIP hormones work similarly to the GLP-1 hormone, helping to regulate the amount of insulin in the body and making you feel fuller quicker

Watch: how to afford GLP-1 in 2026 A breakdown of GLP-1 pricing, insurance coverage pathways, and the new programs making these medications more affordable in 2026

Conclusion GLP-1RA and SGLT2-I are efficacious second-line treatments for T2DM with limited risk of hypoglycemia and positive or neutral effects on CV risk, weight, and BP