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Some tirzepatide users notice that their tolerance to caffeine shifts as they eat and drink less

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But we are not yet at the stage of calling GLP-1 a primary ADHD therapy

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When combined, patients may experience: Excessive appetite suppression , leading to inadequate caloric intake Unintended weight loss beyond therapeutic targets Nutritional deficiencies if dietary intake becomes severely restricted Difficulty maintaining energy for daily activities Hypoglycemia risk in patients also taking insulin or sulfonylureas, due to reduced food intake Gastrointestinal effects may also be compounded

Most cases are mild and resolve with dose adjustment