abbvie glp-1 receptor agonists weight management diabetes treatments agonist What's New in Obesity Treatment? Is GLP-1 Safe for Weight

Research shows that about one in three people stop taking GLP-1s within the first year, and about half stop after one year

It was the most effective antidiabetic agent anyone had ever seen, says Andrew Young, former vice president of research at Amylin Pharmaceuticals, the San Diegobased company that brought Byetta to market

GLP-1 RAs lower fasting insulin and improve HOMA-IR indices, thereby decreasing circulating androgens and promoting follicular maturation

Liraglutide ameliorates cognitive decline by promoting autophagy via the AMP-activated protein kinase/mammalian target of rapamycin pathway in a streptozotocin-induced mouse model of diabetes

However, emerging lawsuits claim the drug caused an eye condition called non-arteritic anterior ischemic optic neuropathy NAION

Discontinued and pipeline GLP-1 medications Discontinued: Albiglutide (Tanzeum): Approved 2014, voluntarily withdrawn 2018