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H., Bays H

GLP-1 agonists are a type of medication that mimics the way the natural hormone, GLP-1, works

The intake captures personal AND family history for medullary thyroid cancer and MEN-2, runs an opt-out exclusionary block on end-stage kidney/liver disease, suicidality, active cancer, organ transplant and severe GI disease, and includes a structured substance/opioid screen with a three-month opiate window requiring free-text date range, name, dose and frequency

Published online June 2, 2026

Additionally, the exploration of the physiological mechanism of GLPs has propelled the research and development of new treatments for cardiovascular diseases and many neurodegenerative conditions, including Alzheimers, Parkinsons, and Huntingtons diseases, all of which being among the leading causes of death globally

Switching is common when: Side effects on the first drug are intolerable The first drug doesn't produce expected weight loss or A1C reduction at maximum tolerated dose Insurance coverage changes Cost on the first drug becomes unsustainable When switching: The new drug usually starts at its lowest dose, not at an "equivalent" higher dose