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One can develop a 505(b)(2) product that uses a different delivery mechanism entirely

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[1] Certain patients should generally avoid NSAIDs, including those with advanced kidney disease, prior complicated ulcers or upper GI bleeding, decompensated heart failure, cirrhosis, or third-trimester pregnancy

While patches are promising, its important to note that GLP-1 patches are still emerging in clinical trials and are not as widely available as injections