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Discussion In this study we show that (i) acute and chronic administration of the GLP-1 receptor agonist Ex-4 results in a significant elevation in heart rate, (ii) centrally administered Ex-4 depresses spectral measures of HRV both acutely and chronically, and (iii) Ex-4 inhibits neurotransmission to cardiac vagal neurons in the nucleus ambiguus

It acts on GLP-1, GIP, and glucagon receptors

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has dropped to 37% in 2025, down from nearly 40% in 2022, coinciding with increased GLP-1 use

Its clinical programme includes obesity, overweight with related medical conditions, type 2 diabetes, knee osteoarthritis symptoms, sleep apnoea, cardiovascular and kidney outcomes, liver disease and chronic low-back pain in defined research populations

North America has the highest number of type 2 diabetes and obesity cases and has a highly developed healthcare system with greater penetration towards innovative therapies propelling GLP-1 analogues growth