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GLP-1 medications are generally not recommended for patients with type 1 diabetes, those with a personal or family history of medullary thyroid carcinoma, or individuals with multiple endocrine neoplasia syndrome type 2

Semaglutides most common side effect, nausea, occurs in over 40% of patients per other clinical trials

These side effects are typically mild to moderate in severity and tend to improve over time

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Indeed, previous reports indicate that GLP-1R signaling is blunted when dynamin-dependent endocytosis is inhibited chemically 10 or genetically 56