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Liraglutide's shorter duration of action compared to weekly formulations means the medication clears the system more quickly, which some patients find easier to manage if side effects occur

Most protocols begin at 2mg weekly, increasing by 2mg every four weeks until reaching the target dose

Tirzepatide faces similar dynamics

an observational substudy of SUMMIT

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(54) found that administering GIPR antagonist to healthy humans reduced postprandial insulin secretion and increased glucose excursions more than administering GLP-1R antagonist (GLP-1RA), indicating that endogenous GIP may play a more significant role in stimulating insulin secretion and reducing postprandial plasma glucose excursions compared to endogenous GLP-1