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Metabolic adaptation deepens as the dose reaches a more therapeutic range

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However, whether this weight loss had a bad effect on OA rats remained to be further studied

17 Conversely, findings from another population-based study suggested there was no overall increased risk of DR associated with GLP-1RA use, while a meta-analysis indicated albiglutide, a GLP-1RA no longer commercially available due to limited prescribing, was associated with an increased risk of early worsening (the four GLP-1RAs available did not exhibit a statistically significant association with DR)

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