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Individual results depend on dose, adherence, side effects, diet, activity, sleep, stress, medical history and follow up

57 On the other hand, the reduction in energy intake during an ad libitum lunch (buffet style) with tirzepatide 15 mg (348.4 kcal) was not significantly different compared to semaglutide 1 mg (284.1 kcal, P =0.19) which may suggest that mechanisms other than reduced food intake and appetite are contributed to the more WL observed with tirzepatide 15 mg versus semaglutide 1 mg

The STEP-1 trial tested the effect of high-dose semaglutide to produce weight loss in people with obesity who do not have diabetes

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Weight Management: The Differentiating Factor Semaglutide: One of semaglutides distinguishing features is its profound impact on weight loss

Common effects may include: Nausea Changes in bowel habits Early fullness Mild injection-site irritation Spacing dose increases appropriately and staying well hydrated can help reduce discomfort