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No safety issues were identified in the CRL, nor did the FDA request any additional studies be conducted, according to Endpoints News

If your semaglutide appears darker yellow, brown, or develops visible particles after proper storage, the medication should not be used

When considering the use of GLP-1R agonists or DPP-IV inhibitors for the treatment of T2DM, it is important to note that DPP-IV inhibitors raise levels of circulating GLP-1 by approximately twofold, whereas GLP-1R agonists exert a dose-dependent pharmacological effect that is considerably more potent since their circulating levels easily exceed endogenous GLP-1 levels by eightfold

The most frequently reported adverse events were nausea and vomiting, affecting 7 patients (35.0%) in the IGB-only group and 10 patients (50.0%) in the IGB + semaglutide group