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SAFETY, TOLERABILITY, AND SPECIAL POPULATIONS The overall safety profile of GLP-1 RAs and multi-agonists is well-characterized from large clinical trials and real-world data

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One of the most consequential changes in 2026 is the loss of exclusivity for semaglutide, beginning in early 2026 across major markets including India, China, Brazil, Turkey and Canada, with semaglutide having lost exclusivity in India on 20th March 2026

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In this regard, in the pancreatic -cell, elevation of both cAMP and cytosolic Ca 2+ and -arrestin signalling downstream of GLP-1R activation are critical events in promoting glucose-dependent insulin secretion