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Inhibitors of DPP-4 participate in the pancreatic-endocrine-osseous axis by increasing endogenous GLP-1

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The incidence of primary composite outcome events was significantly lower in those treated with GLP1RAs compared with those treated with DPP4is (2.59 vs 4.22 events per 1000 person-years

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Limited evidence exists on the risks associated with switching between GLP-1 agonists, emphasizing the need for clinical awareness

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