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GLP-1 medications are recommended in the ADA Standards of Care for those with cardiovascular disease, heart failure, and/or kidney disease to reduce the risk of adverse events due to these conditions

As in the case of GLP-1RA, the significance of this finding which is reversible with discontinuation of therapy is unclear

Its safety in individuals over 75 years of age is not established

10.1056/NEJMOA2108269 18 GiuglianoD.ScappaticcioL.LongoM.BellastellaG.EspositoK

41 Overall, oral semaglutide, the single oral GLP1-RA agent, seems to be an effective and safe hypoglycemic agent in T2DM and might be considered as a promising future alternative option and an add-on therapy to further improve Hb1Ac and reduce weight, while securing a low risk of hypoglycaemic episodes

Sie frdern die Bildung kurzkettiger Fettsuren wie Butyrat, die direkt die GLP-1-Ausschttung stimulieren