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Those are the high-impact variables

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As an embodiment of the present invention, the base-water-organic solvent is selected from any one of a triethylamine/water/acetonitrile system, N-diisopropylethylamine/water/acetonitrile, N-diisopropylethylamine/water/N, N-dimethylformamide and N, N-diisopropylethylamine/water/N, N-dimethylacetamide system

There is limited data on the impact of repeated stopping and starting on long-term outcomes

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