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10.1073/pnas.1411131111 Proc

From your body weight, using the 1.21.6 g/kg range proposed by the 2025 multi-society GLP-1 nutrition advisory for protecting muscle during weight loss
PubMed: 28099824 This statement has not been evaluated by the Food and Drug Administration

K., Renzi, G., & Olek, R

ATTAIN 1 clinical trial demonstrates that individuals with overweight and obesity who used the highest dose of orforglipron (36 mg) lost 12.4% of body weight after 72 weeks

Muscle tissue is metabolically expensive, meaning the body will shed it to save energy unless there is a demand placed upon it
