retatrutide phase 3 2025 triple agonist glp-1 gip glucagon Retatrutide, a (GLP1, GIP, glucagon), just released 2 trial results demonstrating 25% weight loss in half of people with #obesity. This amount of weight loss has not been accomplished PDB-101: Molecule of the Month:
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10.1136/bmj.q1645 [DOI] [PubMed] [Google Scholar] 10.Gulak MA, Murphy P

Furthermore, the odds ratio increases as the cumulative dose increases

However, this reduced side effect profile reflects reduced efficacy, not superior safety or outcomes

PMID: 8462365

Nauck M, Weinstock RS, Umpierrez GE, Guerci B, Skrivanek Z, Milicevic Z
The easiest way to get exposure to this trend is with LLY and NVO, as their duopoly will maintain until at least 2027
