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The dual GIP/GLP-1 mechanism appears to be more effective than GLP-1 alone, which is why researchers continue developing multi-receptor agonists

Future studies should explore depressive symptoms in diabetes patients treated with anti-inflammatory agents, particularly in comorbid populations

By simultaneously activating both GIP and GLP 1 receptors, tirzepatide engages complementary and potentially synergistic mechanisms involved in energy balance and glucose regulation

FXR, a key nuclear receptor of lipoprotein metabolism in the liver, is activated by bile acids, which are metabolic signaling molecules assisting lipid absorption, facilitating digestion, and regulating lipid metabolism and inflammation

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