does semaglutide help with water retention Make You Bloated? Causes and Management Woman shares journey of weight

Pelvic floor physical therapy can bring you the relief you need while helping you stick to your GLP-1 medication plan

FDA-approved as Mounjaro for type 2 diabetes and Zepbound for chronic weight management, tirzepatide targets both GIP and GLP-1 receptors to improve glucose regulation, reduce appetite, and promote weight loss

Importantly, the pivotal cardiovascular and obesity outcome trials of GLP-1RAs, including the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN), Semaglutide Treatment Effect in People with obesity (STEP), and SURPASS (tirzepatide) programs, did not report clinically meaningful increases in AITD or sustained thyroid dysfunction [7,8,30]

This process takes less than five minutes and becomes automatic after a few weeks

However, it is important to avoid unrealistic promises

Then, a May 2025 NEJM head-to-head study comparing tirzepatide with semaglutide confirmed that Mounjaro led to greater mean weight loss and waist reduction over 72 weeks