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Individuals were followed from index date until the first stroke event (for the primary outcome analysis), end of enrolment in their insurance plan or the end of the study period (30 September 2020), whichever was earliest

Genetic predispositions in GLP-1 receptor pathways, appetite regulation, and fat metabolism may influence how your body responds to therapy

In rodents, GLP-1 receptors are abundantly expressed on thyroid C-cells (parafollicular cells) that produce calcitonin, but this expression is much more limited and variable in humans

In other words, BMI often becomes non-significant once you account for waist circumference

Understanding these potential effects involves looking at the drugs direct mechanism, the indirect consequences of weight loss, and individual hormonal responses

If this is an issue, ensuring room temperature and using the ice/numbing techniques above usually resolves it