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105 These results were supported by Srinivasan et al., 106 showing in their study an improvement in weight and insulin sensitivity, where using GLP-1RAs in monotherapy versus metformin achieved more than 5% weight loss

It simultaneously activates three crucial receptors involved in appetite regulation and glucose metabolism: GIP (Glucose-Dependent Insulinotropic Polypeptide) Receptor: GIP is an incretin hormone that stimulates insulin release in response to glucose and may also have effects on fat metabolism

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[37,38] Another well-established intervention is the ketogenic diet, which lowers insulin levels, increases ketone body production, enhances GABA synthesis, and improves mitochondrial efficiency, thereby stabilizing neuronal excitability